Effect of Danchi Decoction on Serum Interleukin of Endometriosis
10.3969/j.issn.1005-5304.2014.06.006
- VernacularTitle:丹赤饮对子宫内膜异位症患者血清白细胞介素的影响
- Author:
Weiwei SUN
;
Yanhuan YANG
;
Zengping HAO
;
Min LI
;
Yan ZHENG
;
Juan ZHANG
;
Ruihua ZHAO
- Publication Type:Journal Article
- Keywords:
endometriosis;
Danchi Decoction;
GnRH-a;
gestrinone;
IL-2;
IL-6
- From:
Chinese Journal of Information on Traditional Chinese Medicine
2014;(6):14-17
- CountryChina
- Language:Chinese
-
Abstract:
Objective Based on the immunologic balance, to investigate the mechanisms of Danchi decoction for controlling the recurrence of endometriosis (EMs) of qi stagnation and blood stasis after conservative operation. Methods A multi-center and randomized clinical trial was adopted. EMs patients were divided into Chinese medicine group (CG, 20 cases) and western medicine group (WG, 10 cases). The two groups were given Danchi decoction and GnRH-a or gestrinone respectively for 3 months. The serum IL-2, IL-6 and IL-2/IL-6 were detected before operation, after 3 months of treatment and 3 months after withdrawal, and compared with the control group (5 cases of simple ovarian cysts). Results Before operation, the serum IL-2 level of CG and WG was lower than control group (P<0.05), IL-6 was higher than control group (P<0.05), the ratio of IL-2/IL-6 was lower than control group (P<0.05). After treatment and 3 months after withdrawal, IL-2 level of CG and WG was increased than before operation (P<0.05), IL-6 was decreased (P<0.05), IL-2/IL-6 ratio was increased (P<0.05). There was no significant difference in IL-2/IL-6 between CG and control group (P>0.05), but 3 months after withdrawal, IL-2/IL-6 of WG was significantly lower than that of control group (P<0.05). Conclusion Immune imbalance is closely related to the occurrence and development of EMs. Danchi Decoction or GnRH-a or gestrinone can prevent the recurrence of EMs by adjusting the disorder of immune response, and Danchi Decoction has better effect on long-term result.
