Use of Compound Lactobacillus acidophilus Tablets in Rescue Therapy for Failed Eradication of Helicobacter pylori
10.3969/j.issn.1008-7125.2014.05.007
- VernacularTitle:复方嗜酸乳杆菌片在幽门螺杆菌根除失败补救方案中作用的研究
- Author:
Fangjun WANG
;
Yi GAO
;
Pengfei LIU
;
Bin XIANG
;
Weidong SHEN
;
Wei ZHANG
;
Tingsong XIA
- Publication Type:Journal Article
- Keywords:
Helicobacter pylori;
Lactobacillus acidophilus;
Bismuth;
Rescue Therapy
- From:Chinese Journal of Gastroenterology
2014;(5):284-287
- CountryChina
- Language:Chinese
-
Abstract:
Background:Helicobacter pylori (Hp)infection is correlated with the development of chronic gastritis,peptic ulcer, mucosa-associated lymphoid tissue lymphoma and gastric cancer.Studies showed that Lactobacillus acidophilus could improve the eradication rate of Hp and reduce the occurrence of side-effects.Aims:To evaluate the efficacy of compound Lactobacillus acidophilus tablets combined with bismuth-containing quadruple therapy for the treatment of failed eradiction of Hp infection.Methods:One hundred and eighty patients with Hp-positive peptic ulcer in whom standard triple therapy failed were enrolled and then randomly assigned into experimental group and control group.Patients in experimental group received compound Lactobacillus acidophilus tablets 1 g tid for 14 days,followed by rabeprazole 10 mg bid +amoxicillin 1 000 mg bid +furazolidone 100 mg bid +bismuth 300 mg qid for 10 days.Patients in control group received rabeprazole 10 mg bid +amoxicillin 1 000 mg bid +furazolidone 100 mg bid +bismuth 300 mg qid for 10 days.13 C-urea breath test was conducted at least 4 weeks after completion of the course,Hp eradication rate and side-effects were evaluated. Results:No significant differences in PP eradication rate and ITT eradication rate were found between experimental group and control group (PP:81.2% vs.78.2%,χ2 =0.241,P =0.623;ITT:76.7% vs.75.6%,χ2 =0.031,P =0.861).Incidences of nausea and vomiting (2.4% vs.11.5%),diarrhea (0 vs.9.2%)in experimental group were significantly decreased than those in control group (P <0.05).Conclusions:Compound Lactobacillus acidophilus tablets combined with bismuth-containing quadruple therapy is efficient for Hp-positive patients with failed standard triple therapy and can reduce side-effects.
