Detecting Thermal Stability of Cefmenoxime Hydrochloride in Infusion Solutions by Classical Isothermal Kinetic Method and Multivariate Linear Model
10.3870/yydb.2014.05.036
- VernacularTitle:经典恒温法和多元线性模型预测头孢甲肟在输液中的热稳定性
- Author:
Jianxin WANG
;
Chenchen ZHANG
;
Jizhang YANG
;
Tixin GU
- Publication Type:Journal Article
- Keywords:
Cefmenoxime;
Thermal degradation kinetic;
Classical isothermal kinetic method;
Multivariate linear model;
HPLC
- From:
Herald of Medicine
2014;(5):668-671
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate thermal degradation kinetic characteristics of Cefmenoxime Hydrochloride in infusion solutions, and predict its thermal stability. Methods The HPLC was applied to determine the contents of Cefmenoxime Hydrochloride. Classical isothermal kinetic method and multivariate linear model were used to predict the expiration date of the injection. Results It was found that the thermal degradation kinetics of Cefmenoxime Hydrochloride in two infusion solutions corresponded with the first-order kinetics. The expiration dates of Cefmenoxime Hydrochloride in 0. 9%sodium chloride injection calculated by two different methods were 2. 20 days and 1. 52 days,and in 5% glucose injection were 2. 09 days and 1. 53 days,respectively. Conclusion The thermal stability of Cefmenoxime Hydrochloride in infusion solutions is poor and its expiration dates are the same calculated by two different methods.
