The clinical value of ANA,anti-dsDNA antibody and anti-ENA antibody repertoire in systemic lupus erythematosus diagnosis

VernacularTitle:ANA、抗dsDNA抗体和抗ENA抗体谱对系统性红斑狼疮的诊断价值
Author: Xiaoyan CHEN ; Yan CHEN ; Yinhui ZHANG ; Ni WANG ; Chunlan LV
Publication Type:Journal Article
Keywords: lupus erythematosus,systemic; antibodies,antinuclear; antibodies,anti-double strand DNA; antibodies,anti-extractable nuclear antigen; diagnosis
From: International Journal of Laboratory Medicine 2014;(9):1131-1133
CountryChina
Language:Chinese
Abstract: Objective To investigate clinical value of the anti-nuclear antibody (ANA ) ,anti-double strand DNA (dsDNA ) anti-body and anti-extractable nuclear antigen(ENA) antibody repertoire in systemic lupus erythematosus (SLE) diagnosis .Methods 158 SLE patients were served as SLE group and another 50 healthy people as the control group .Indirect immunofluorescence(IIF) and immunoblotting test(IBT ) were employed to detect ANA ,anti-dsDNA antibody and anti-ENA antibody repertoire .Results Positive rates of ANA ,anti-dsDNA antibody and anti-ENA antibody repertoire in SLE diagnosis were 81 .65% ,68 .35% and 87 .34% ,respectively ,which were all lower than that of their combined detection (93 .04% ) ,with statistically significant difference (P<0 .05 ) .Among anti-ENA antibody repertoire ,the positive rate of anti-U1-nuclear ribonucleoprotein (U1-Nrnp ) antibody (52 .53% ) was the highest .Conclusion Combined detection of ANA ,anti-dsDNA antibody and anti-ENA antibodies repertoire has some clinical value of early diagnosis of SLE .