Siraitia grosvenori and rehmannia glutinosa promote the hematopoietic stem cells and progenitor cells proliferation and function
10.3969/j.issn.1671.7856.2014.003.011
- VernacularTitle:罗汉果和熟地增加小鼠造血干细胞的数量和功能
- Author:
Lin BAI
;
Guiying SHI
;
Yajun YANG
;
Lianfeng ZHANG
- Publication Type:Journal Article
- Keywords:
Siraitia Grosvenor;
Rehmannia Glutinsa;
Flow cytometry;
Hematopoietic stem cell
- From:
Chinese Journal of Comparative Medicine
2014;(3):50-54
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the influence of Siraitia Grosvenori and Rehmannia Glutinosa on the Hematopoietic stem cells proliferation and function .Methods Cells from the peripheral blood , spleen and bone marrow of mice were stained with indicated antibodies , and analyzed by flow cytometry .Mice were divided 3 groups:control group, Siraitia Grosvenori treatment group and Rehmannia Glutinosa treatment group .After 4.5Gy IR treatment, mice divided 4 groups: control group, 4.5Gy IR treatment and feed with normal food, 4.5Gy IR treatment and feed with Siraitia Grosvenori and 4.5Gy IR treatment and feed with Rehmannia Glutinosa for 1 month.Results Mice fed with Siraitia Grosvenori and Rehmannia Glutinosa decreased the percentage of B cells and increased the percentage of M cell .For HSCs, the number of HSCs was increased , especially the number of LT-HSCs.After 4.5Gy IR treatment, mice fed with Siraitia Grosvenori and Rehmannia Glutinosa increase the number of HSCs , and increased the percentage of M cells . Conclusion Siraitia Grosvenori and Rehmannia Glutinosa promote the hematopoietic stem cells and progenitor cells proliferation and function and recover the damage that caused by IR treatment .
