Syk and VEGF-C in breast cancer's expression with lymph node metastasis
10.3969/j.issn.1000-484X.2014.05.025
- VernacularTitle:Syk和VEGF-C在乳腺癌组织中的表达与淋巴结转移的关系
- Author:
Xifeng ZHANG
;
Hongbing ZHAO
- Publication Type:Journal Article
- Keywords:
Breast cancer;
Syk;
VEGF-C
- From:
Chinese Journal of Immunology
2014;(5):681-683
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the relationship of Syk and VEGF-C expression in breast cancer with lymph node metastasis . Methods:The expression of Syk and VEGF-C in 40 cases of breast cancer were determined using immunohistochemistry assay .Then, the positive rates of Syk and VEGF-C were compared with lymph node metastasis .Results:The expression rate of VEGF-C and Syk in breast cancer was respectively 77.5%(31/40), 37.5%(15/40).VEGF-C protein expression was not significant related with the tumor diameter (P>0.05) and histological grade (P>0.05), but was significantly associated with lymph node metastasis (P<0.05).Syk protein expression was not significant related with tumor diameter (P>0.05) and the histological grade(P>0.05), and was associated with lymph node metastasis (P<0.05).The difference of Syk and VEGF-C had statistics significance(P<0.05).Con-clusion:Syk and VEGF-C involved in the lymphatic invasion and metastasis , may be an important indicator of prognosis .
