Effective of anticancer mouse monoclonal antibody against hMIC-1 targets pancreatic tumor for nude mice in vivo
10.3969/j.issn.1671.7856.2014.003.004
- VernacularTitle:鼠抗人hMIC-l单克隆抗体抑制裸鼠移植人胰腺癌体内研究
- Author:
Zhaoyang LIU
;
Xiaobing WANG
;
Wei ZHANG
- Publication Type:Journal Article
- Keywords:
Mouse original monoclonal antibody against hMIC-1;
Pancreatic tumor;
PANC-1;
SW1990;
Inhibitive tumor action;
In vivo
- From:
Chinese Journal of Comparative Medicine
2014;(3):14-19
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate a antitumor effects of mouse original monoclonal antibody against hMIC -1 as intravenous administration with human pancreatic tumor in vivo and providing experimental data .Methods The fourty-eight mice were randomized into eight groups for loaded with two pancreatic tumor cell lines panc -1 or sw1990 respectively , and individual tumor growth was observed , antitumor efficacy was evaluated after using mouse original monoclonal antibody against hMIC-1 by intravenous administration .The pathological change with formalin fixed , paraffin embedded tissues section was viewed .Results There was a significant difference in tumor volume and weigt in intravenous injection of mouse original monoclonal antibody against hMIC-1 on load pancreatic tumor with nude mice group compared with that in the control group after four week treatment , and the mouse original monoclonal antibody against hMIC-1 demonstrated a close association between inhibition of tumor volume growth and dose-effective in the two xenograft models examined .Under examined microscope , the pancreatic tumor tissue was destroyed evidently in mouse original monoclonal antibody against hMIC-1 group.Conclusions The antitumor effect of intravenous injection for mouse original monoclonal antibody against hMIC-1 is better than that of systemic using gemcitabine .
