Research Progress of protective effect of intestinal trefoil factor on the gastrointestinal tract
- VernacularTitle:肠三叶因子对胃肠道保护作用的研究进展
- Author:
Xiang XUE
;
Shinan NIE
- Publication Type:Journal Article
- Keywords:
Intestinal trefoil factor;
Mucin;
Migration;
Immunity;
Mucosal
- From:
Journal of Medical Postgraduates
2014;(4):439-443
- CountryChina
- Language:Chinese
-
Abstract:
Intestinal trefoil factor (ITF or TFF3) is a member of trefoil factor family which is most studied , mainly in the in-testinal tract .TFF3 plays an important role in gastrointestinal mucosal protection and epithelial repair .Action mechanism includes in-teraction with mucin, migration, anti-apoptosis, angiogenesis, immune regulation, interaction with its receptor, etc.Recombinant TFF3 has been approved as a national drug and its therapeutic indications for repair mucosa , prevention and treatment of gastrointesti-nal ulcers and inflammation .Furthermore, the classic TFF3 receptor and signaling pathway is highly valuable to make TFF 3 become an effective treatment for gastrointestinal injury disease .
