Quantitative low attenuation areas of every lung lobe assessment of pulmonary function loss by MDCT in COPD patients
10.3969/j.issn.1002-1671.2014.04.018
- VernacularTitle:MSCT在评估慢性阻塞性肺疾病患者肺功能受损的应用
- Author:
Lin WANG
;
Guangli WANG
;
Chengqi ZHANG
- Publication Type:Journal Article
- Keywords:
pulmonary emphysema;
quantitative computed tomography;
pulmonary function test;
chronic obstructive pulmonary disease
- From:
Journal of Practical Radiology
2014;(4):613-616
- CountryChina
- Language:Chinese
-
Abstract:
Objective To determine the capability of quantitative low attenuation areas volume percentage(LAA%)in individual lobes to assess pulmonary function loss and disease severity in pulmonary COPD patients.Methods A total of 80 subjects (50 COPD patients;30 normal smokers),who all were smokers,underwent pulmonary function tests(PFTs)and Chest CT examination at full inspiration.For the quantitative assessment,percentage of low attenuation areas were automatically calculated for each lobe by the post processing software(Thoracic VCAR).To study the correlation between these CT parameters and lung function(FEV1% pre-dicted,FEV1/FVC,DLCO%predicted,RV/TLC),univariate linear regression analysis was performed.CT measurements were compared between the five groups with analysis of covariance(ANCOVA).Results FEV1 and FEV1/FVC had significant correla-tions with all of these CT parameters.DLCO、RV/TLC had significant correlations with these parameters,aside from the LAA% of right middle lobe and right inferior lobe.The LAA% in left upper lobe have the highest correlation with FEV1、DLCO、RV/TLC. However,FEV1/FVC have the highest correlation with the LAA% of right lower lobe.The LAA% of Right lung,right upper lobe,and whole lung were significantly different between the non-COPD group and GOLD1 group.Conclusion Whole lung and every lung lobe low attenuation areas volume percentage were reflected the lung function impairment in COPD patients.
