A clinical observation on therapeutic effect of traditional Chinese medicine granules made by formula of ;Shegan Mahuang decoction for treatment of patients with asthma
10.3969/j.issn.1008-9691.2014.02.001
- VernacularTitle:射干麻黄汤中药配方颗粒治疗哮喘的疗效观察
- Author:
Shuo YANG
;
Guangwei LUO
;
Xiaoping HU
;
Jun WAN
;
Qian XIA
;
Jing CHEN
;
Wensheng YUAN
;
Jiemin SUN
- Publication Type:Journal Article
- Keywords:
Shegan Mahuang decoction;
Bronchial asthma;
Pulmonary function;
Integrative traditional Chinese and western medicine therapy
- From:
Chinese Journal of Integrated Traditional and Western Medicine in Intensive and Critical Care
2014;26(2):81-83
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the therapeutic effect of traditional Chinese medicine(TCM)granules made by the formula of Shegan Mahuang decoction for treatment of patients with asthma. Methods A prospective study was conducted,51 cases of light to moderate asthma(cold type)patients were randomly divided into treatment group (25 cases)and control group(26 cases). Conventional symptomatic treatments were of the same in two groups. The patients in control group were given salbutamol aerosol inhalation,100μg each time,4 times per day;based on the treatment of the control group,additionally the above mentioned TCM granules dissolved in water was administered orally 1 dose/day taken twice once in the morning and another once in the evening in treatment group. The therapeutic course was 12 weeks in both groups. Before and after treatment,the asthma control test(ACT)score,forced expiratory volume in 1 second(FEV1)and peak expiratory flow(PEF)were observed. The therapeutic effect,adverse reaction and compliance were evaluated. Results The number of patients with asthma completely controlled in the treatment group was significantly higher than that in the control group(16 cases vs. 9 cases,χ2=4.82,P=0.028). In the patients of two groups,FEV1,PEF and ACT scores were significantly improved after treatment,and in the treatment group,they were obviously higher than those in control group〔FEV1(L):2.67±0.46 vs. 2.32±0.47,PEF(L/min):327.6±49.4 vs. 273.1±42.8,ACT score:22.8±2.0 vs. 21.1±2.6,all P<0.05〕. After treatment,FEV1%predicted value was increased in the treatment group but decreased in control group,there was significantly statistical difference〔(0.68±0.07)% vs.(0.80±0.11)%,P<0.05〕,no significant adverse reaction was found,compliance was good. Conclusion TCM granules made by formula of Shegan Mahuang decoction can improve the clinical symptoms, pulmonary function and control level in patients with asthma,so it is an effective medicine for the control of asthma.
