Influence and mechanism of obesity on the onset of pubertal development in obese children

VernacularTitle:肥胖对儿童青春期性发育的影响及作用机制
Author: Junfen FU ; Xuelian ZHOU
Publication Type:Journal Article
Keywords: Obesity; Sexual development; Leptin; Kisspeptin Lin28B
From: Chinese Journal of Applied Clinical Pediatrics 2014;29(8):574-577
CountryChina
Language:Chinese
Abstract: Timing of puberty showed a dramatic decrease in the past decades,and it depends on the gene,nutrition,environment,social economics,and so on.Childhood obesity affects both the timing of puberty and sex hormone levels.However,the influence of obesity on the timing of puberty has gender differences.Current studies show that childhood obesity accelerates the onset of puberty in girls,but it still has controversy in boys.Mechanisms of concrete have not clear,may be related to the subjectivity of standard of male sexual development and the correlation of body mass index as a substitute for male obesity is poor.Through literature review at home and abroad,this article will explain the influence of obesity on the timing of puberty,sex hormone levels and its gender differences,further explore the possible mechanisms of body fat participate in starting the gonad axis,and provide new research direction on the switch for the gonad axis.