Effect of atorvastatin on cardiac function and HGF/c-Met signaling path-way after acute myocardial infarction in diabetic rats
10.3969/j.issn.1000-4718.2014.04.015
- VernacularTitle:阿托伐他汀对糖尿病大鼠急性心肌梗死后心功能及HGF／c-Met 信号通路的影响
- Author:
Guangdong YAN
;
Zicheng LI
;
Jianhao LI
;
Zaiyong ZHANG
;
Shanjun ZHAO
;
Wenzhu ZHANG
- Publication Type:Journal Article
- Keywords:
Diabetes mellitus;
Acute myocardial infarction;
Cardiac function;
Hepatocyte growth factor;
Atorvastatin
- From:
Chinese Journal of Pathophysiology
2014;33(4):658-663
- CountryChina
- Language:Chinese
-
Abstract:
AIM:To investigate the effect of atorvastatin on myocardial apoptosis , ventricular remodeling and cardiac function after acute myocardial infarction (AMI) in diabetic rats, and to explore whether the effect is mediated by hepatocyte growth factor ( HGF)/c-Met signaling pathway .METHODS:Diabetes in 70 male SD rats was induced by in-traperitoneal injection of streptozotocin (STZ, 65 mg/kg).After 8 weeks, AMI was induced by the ligation of the left ante-rior descending coronary artery in the diabetic rats , and 32 surviving rats were divided into AMI group (n=16) and AMI+atorvastatin group ( n=16, 20 mg· kg -1 · d-1 ) at random.The similar surgical procedure was completed in sham group (n=11) without coronary ligation.Atorvastatin was given daily by gavage from the first day after AMI .Two weeks later, the cardiac function , pathological changes of myocardial tissues , myocardial apoptosis , and the expression of HGF and c-Met were compared among groups .RESULTS: AMI significantly reduced cardiac function , increased collagen volume fraction ( CVF) and myocardial apoptotic index , and up-regulated the expression of HGF and c-Met at mRNA and protein levels in AMI control group (P<0.05).The cardiac function was improved , and CVF and myocardial apoptotic index were reduced by the treatment with atorvastatin , which also up-regulated the expression of HGF and c-Met (P<0.05).CON-CLUSION:Atorvastatin significantly attenuates myocardial apoptosis and cardiac remodeling , and improves cardiac func-tion after AMI in diabetic rats by further enhancing the activation of HGF /c-Met pathway .
