Influence of 8-week swimming on peripheral neuropathy in type 2 diabetic rats
10.3969/j.issn.1000-4718.2014.04.026
- VernacularTitle:8周游泳运动对2型糖尿病大鼠周围神经病变的影响
- Author:
Huayu SHANG
;
Zhi XIA
;
Dan ZHANG
;
Meimei HUANG
;
Ruonan SHANGGUAN
;
Quansheng SU
- Publication Type:Journal Article
- Keywords:
Diabetic peripheral neuropathy;
Exercise;
Nerve conduction velocity;
Tumor necrosis factor α;
Interleukin 6;
C-reactive protein
- From:
Chinese Journal of Pathophysiology
2014;33(4):719-724
- CountryChina
- Language:Chinese
-
Abstract:
AIM:To explore the influence of long-term swimming on peripheral neuropathy in type 2 diabetic rats.METHODS:Male Wistar rats were fed with a high-fat and high-fructose diet, and injected with streptozocin to estab-lish a model of type 2 diabetes mellitus.The rats were randomly divided into 4 groups:blank control group (C group), ex-ercise control group ( CE group ) , diabetes mellitus group ( DM group ) and diabetes mellitus +exercise group ( DME group).The rats in CE group and DME group received 8-week swimming training (6 d/week).The training time was 20, 30 and 45 min in the first 3 d,respectively, and then it increased to 60 min a day.Eight weeks later, the motor nerve conduc-tion velocity ( MNCV ) and the levels of tumor necrosis factor α( TNF-α) , interleukin 6 ( IL-6 ) and C-reactive protein ( CRP) in sciatic nerve tissues of the rats were measured .The morphological changes of the sciatic nerve were also observed under light microscope .RESULTS:Compared with DM group , 8-week swimming obviously accelerated the MNCV ( P<0.05), decreased the levels of TNF-α, IL-6 and CRP in DME group (but no significant difference, P>0.05).The obvi-ous nerve injury in DM group was observed .However , the pathological change of the sciatic nerve in DME group was re-lieved.CONCLUSION:Eight-week swimming training significantly accelerates the MNCV , attenuates the nerve injury in diabetic rats and has protective effect on peripheral nerve , which may be correlated with relieving the inflammatory reaction .
