Correlation of ABCG2 expression with the efficacy of irinotecan chemotherapy in colorectal cancer patients
10.3969/j.issn.1000-8179.20132030
- VernacularTitle:结直肠癌中ABCG2表达与伊立替康为基础化疗疗效相关性研究
- Author:
Zhiwei SUN
;
Xicheng WANG
;
Jing GAO
;
Yanyan LI
;
Xiaodong ZHANG
;
Lin SHEN
- Publication Type:Journal Article
- Keywords:
ABCG2;
CPT-11;
colorectal cancer
- From:
Chinese Journal of Clinical Oncology
2014;(7):430-433
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To identify the ABCG2 expression levels in colorectal cancer patients and its relationship with clinicopath-ological features and the efficacy of irinotecan-based chemotherapy and to provide further theoretical basis for individualized treatment. Methods:Clinical data and tumor samples from patients with metastatic CRC who have received irinotecan-based chemotherapy at the Department of Gastroenterological Oncology, Peking University Cancer Hospital from January 1996 to December 2011 were collected. The immunohistochemical method was used to detect ABCG2 expression levels both in colorectal carcinoma and tumor-adjacent nor-mal tissues. The correlations of the expression of ABCG2 with clinicopathological features and the efficacy of irinotecan-based chemo-therapy were statistically analyzed. Results:1) Immunohistochemical staining shows that the positive rate of ABCG2 expression in the colorectal cancer samples is 93.2%, which is significantly higher than that in normal colon mucosa at 43.6%(P<0.05). No significant as-sociations were observed between ABCG2 expression and age, gender, tumor differentiation, primary tumor sites, or liver metastasis.(2) ABCG2 expression has no significant correlation with the efficacy of irinotecan-based chemotherapy (P>0.05). Conclusion:ABCG2 expression has no significant correlation with the efficacy of irinotecan chemotherapy in patients with colorectal cancer.
