Clinical treatment of extensive-stage small cell esophageal cancer
10.3969/j.issn.1000-8179.2014.20131774
- VernacularTitle:广泛期小细胞食管癌的治疗策略
- Author:
Chao JIANG
;
Huanhuan WANG
;
Maobin MENG
;
Zhiyong YUAN
- Publication Type:Journal Article
- Keywords:
small-cell esophageal cancer;
radiotherapy;
chemotherapy
- From:
Chinese Journal of Clinical Oncology
2014;(7):434-438
- CountryChina
- Language:Chinese
-
Abstract:
Objective: Small-cell esophageal cancer (SCEC) is a rare malignant tumor. Radiotherapy and chemotherapy have been considered as standard treatments for limited-stage SCEC (LS-SCEC). This study aimed to analyze the comprehensive treatment and prognosis of extensive-stage SCEC (ES-SCEC). Methods: We retrospectively analyzed the clinical data of 35 Patients with ES-SCEC from the Cancer Hospital of Tianjin Medical University between January 1989 and April 2012. Results:A total of 33 patients (94.3%) participated in follow-up visits. The overall survival of the patients ranged between 0.6 and 42.4 months with a median of 9.5 months. All of the patients suffered from extensive metastasis. Among these patients, 33 manifested metastasis at diagnosis and 2 showed metastasis after surgery. One-and two-year survival rates were 27.2%(9/33) and 9.0%(3/33), respectively. Univariate and mul-tivariate analysis results revealed that the number of chemotherapy cycles (≥4) is a risk factor of OS (P=0.02) and the only indepen-dent risk factor (P=0.049). Conclusions:ES-SCEC is a malignant tumor with poor prognosis. Radiotherapy could not improve patient survival. Chemotherapy combined other therapeutic procedures could be considered as an effective treatment.
