Application of rituximab therapy on refractory nephrotic syndrome in children
10.3760/cma.j.issn.2095-428X.2014.05.002
- VernacularTitle:利妥昔单抗在儿童难治性肾病中的应用
- Author:
Jianping HUANG
;
Juan DU
- Publication Type:Journal Article
- Keywords:
Nephrotic syndrome;
Rituximab;
Child
- From:
Chinese Journal of Applied Clinical Pediatrics
2014;29(5):324-326
- CountryChina
- Language:Chinese
-
Abstract:
Primary nephrotic syndrome (PNS) is one of the most common forms of glomerular disorder in chil dren.It is reported that over 90％ of patients are due to minimal change disease and most respond to glucocorticoid (GC) therapy.However,76％-93％ cases have relapses and 40％-50％ frequently relapses nephritic syndrome or steroid dependent nephritic syndrome when steroid is tapered.Long-term courses of GC and immunosuppressant will place them at increased risk for severe side effects.Not all patients do respond to therapy.Although most reports on rituximab use in pediatric patients have not recognized significant side effects,the long-term adverse events of rituximab are not known.Thus,controlled long-term studies are required to be done to assess the risk-benefit profile of rituximab in childhood nephrotic syndrome.
