Research on correlation between GGCX(rs6738645) polymorphism and warfarin stable dose
10.3969/j.issn.1671-8348.2014.10.010
- VernacularTitle:GGCX（rs6738645）基因多态性与华法林稳定剂量的关系
- Author:
Yinqiang LIU
;
Baihui YANG
;
Jianming XIA
;
Xueyu ZHANG
;
Guimin ZHANG
- Publication Type:Journal Article
- Keywords:
gamma-glutamyl carboxylation;
gene polymorphism;
warfarin;
heart valve prosthesis implantation
- From:
Chongqing Medicine
2014;(10):1184-1186
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the gamma glutamine carboxylase (GGCX ,rs6738645) genotype distribution in Chinese Han population and the correlation between GGCX (rs6738645) polymorphism and the warfarin stable dose in the patient after valve replacement .Methods The genotypes of 228 cases were detected by the Snapshot technology in order to explore the genotype and allele frequencies .The correlation between the gene polymorphism in 176 cases after valve replacement and the stable dose of warfa-rin was compared .Results In total of 228 research subjects ,the number of TT ,GT and GG genotype were 84(36 .84% ) ,122 (53 .51% ) and 22(9 .65% ) .The frequencies of T and G allele were 63 .60% and 36 .40% respectively ;in 176 patients after the valve replacement ,the maintenance stable dose of warfarin was lower in GG group than in the TT and GT groups ,the differences between the groups showed statistical significance (P<0 .01) .The PT value and INR value had no statistical difference among 3 genotype groups(P>0 .05) .Conclusion The GGCX(rs6738645) polymorphism in Chinese Han population may be the influencing factor of warfarin individual dose difference in the patients after valve replacement .
