Effect of Puerarin on Expression of NF-κB in Rats with Acute Lung Injury Induced by Oleic Acid
- VernacularTitle:葛根素对油酸致大鼠急性肺损伤组织中核因子-κB 表达的影响
- Author:
Chunyan WU
;
Zhi ZHANG
;
Weiwei GU
;
Ronghua MA
;
Jun MA
- Publication Type:Journal Article
- Keywords:
Puerarin;
Acute lung injury;
Oleic acid;
NF-κB
- From:
China Pharmacist
2014;(5):732-734
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To observe the expression of nuclear factor-kappa B( NF-κB) in rats with acute lung injury ( ALI) caused by oleic acid ( OA) and investigate the protective effect of puerarin ( Pue) in ALI. Methods:Twenty-four rats were randomly divided into three groups:the control group, OA group and Pue group. Morphological changes in lung tissues were observed under a light mi-croscope and the expression of NF-κB in lung tissues were examined. Results:Morphological changes in lung tissues showed that pul-monary inflammation was relieved in Pue group compared with that in OA group. Compared with the control group, the expression of NF-κB was increased obviously in OA group (0. 39 ± 0. 07 vs 0. 12 ± 0. 04, P<0. 05), and that was decreased obviously in Pue group (0. 24 ± 0. 05), which was still higher than that in the control group (P<0. 05). Conclusion:Puerarin can alleviate the inflammation reaction in ALI through inhibiting the expression of NF-κB.
