Preparation and Quality Control of Loxoprofen Sodium Patches
- VernacularTitle:洛索洛芬钠贴片的研制及质量控制
- Author:
Manman HU
;
Jinlai LIU
;
Xiaohui LI
;
Zhong LIN
- Publication Type:Journal Article
- Keywords:
Loxoprofen sodium patches;
Preparation;
HPLC;
Quality control
- From:
China Pharmacist
2014;(5):755-757
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the preparation and quality control of loxoprofen sodium patches and develop an HPLC method for the determination of loxoprofen sodium. Methods:Loxoprofen sodium patches were prepared with CMC-Na and PVP as the adjuvants, and an HPLC method was used to determine the content of loxoprofen sodium. Results:The linear range of loxoprofen sodium was 4-24μg·ml-1(r=0. 999 7), the average recovery was 99. 99%(RSD=0. 99%, n=6). Conclusion:The preparation method is reason-able, simple and stable. The developed HPLC method is specific to determine the content of loxoprofen.
