Antibacterial Activity of Compounds from Rabdosia rubescens
10.11842/wst.2014.03.031
- VernacularTitle:冬凌草抗菌活性成分研究
- Author:
Gaoshen LI
;
Wei ZHANG
;
Tao PENG
;
Meizhen GUO
- Publication Type:Journal Article
- Keywords:
Rabdosia rubescens;
antibacterial activity;
Staphlococcus aureus;
Methcillin-resistant Staphylococcus aureus;
β-lactamase positive Staphylococcus aureus
- From:
World Science and Technology-Modernization of Traditional Chinese Medicine
2014;(3):610-613
- CountryChina
- Language:Chinese
-
Abstract:
This study was aimed to assay the antibacterial activity of compounds from Rabdosia rubescens. Disc dif-fusion (K-B method) was used to screen the in vitro antibacterial activity. All kinds of chromatography were used to isolate the chemical constituent and structure was identified by MS and NMR spectroscopy. The results showed that six compounds were isolated and identified as oridonin (1), rosmarinic acid (2), caffeic acid (3), salicylic acid (4), ferulic acid (5), vanillic acid (6). Oridonin had activity against Staphylococcus aureus (SA), Methcillin-resistant Staphylococcus aureus (MRSA), β-lactamase positive Staphylococcus aureus (ESBLs-SA), and showed the highest ac-tivity (MIC is 3.125, 6.25 and 6.25 μg·disc-1, respectively), but was still weaker than that of berberine as positive control (MIC is 0.156 μg·disc-1). Ferulic acid had activity against SA and MRSA (MIC is 50 and 50 μg·disc-1, re-spectively). Salicylic acid had only activity against SA (MIC 50 μg·disc-1). It was concluded that oridonin, ferulic acid and salicylic acid were the main antibacterial activity compounds from R. rubescens.
