The effect of diabetes on the bone metabolism
10.3760/cma.j.issn.1008-1372.2014.02.004
- VernacularTitle:糖尿病对骨代谢的影响
- Author:
Houde ZHOU
;
Xiaofei MAN
;
Zhiguang ZHOU
- Publication Type:Journal Article
- Keywords:
Diabetes mellitus;
Osteoporosis
- From:
Journal of Chinese Physician
2014;(2):156-160
- CountryChina
- Language:Chinese
-
Abstract:
The relationship between diabetes and osteoporosis has gradually become a new research hotspot , but is still much controversy .High concentration of blood glucose can be bond to varieties of proteins in vivo and form glycosylation end products in col -lagen tissue and reduce bone strength , besides it can inhibit RANKL induced osteoclast formation and bone resorption by repressing redox-sensitive NF-kappa B activity .A series of diabetes mellitus complications can induce less local bone nutrition supply and calcium and phosphorus sorption , reduce muscle tension and bone mineral density , which leads to the increase of fracture risk .Type 2 diabetes patients with overweight or obesity often have increased secretion of inflammation factors , adiponectin and leptin , which promotes the formation of osteoclasts and encourages bone marrow stromal stem cells to differentiate into adipocytes ;On the other hand , adiponectin and leptin can facilitate osteoblasts proliferation , differentiation and activity , and promotes bone formation .This article will discuss how diabetes works on bone metabolism and the underlying pathophysiological and physiological mechanism .
