Preparation and Release Determination of Compound Isosorbide Mononitrate Sustained-release Capsules
- VernacularTitle:复方单硝酸异山梨酯缓释胶囊的制备及释放度测定
- Author:
Jihong GUO
;
Shuangyan GUO
- Publication Type:Journal Article
- Keywords:
Isosorbide mononitrate;
Aspirin;
Compound sustained-release capsules;
Preparation;
Release
- From:
China Pharmacist
2014;(5):769-773
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To prepare compound isosorbide mononitrate sustained-release capsules and study the drug release. Meth-ods:Isosorbide mononitrate pellets were prepared by the fluidized bed coating technology. The influencing factors in the preparation process were examined and the major factors were optimized by single factor experiments. The drug release was determined by HPLC. The best formula was screened by optimizing aspirin coating solution. Results:The compound isosorbide mononitrate sustained-release capsules were prepared by the best formula. Both the two drugs could achieve promising release, and in vitro release behavior of isosor-bide mononitrate was fitted Higuchi equation,which was similar to that of the imported preparations. The release of aspirin in acidic and alkaline media was in coincidence with the release requirements. Conclusion:The formula is reasonable and the preparation process is stable with promising sustained release property.
