Optimization of Ethanol Precipitation Technique for Fufang Shenqi Soft Capsules by Orthogonal Design
- VernacularTitle:正交试验优选复方参芪软胶囊的醇沉工艺
- Author:
Chunyan WANG
;
Jianchun YANG
;
Yunxia LI
;
Chunwen MA
- Publication Type:Journal Article
- Keywords:
Fufang Shenqi soft capsules;
Orthogonal design;
Ethanol precipitation technique;
Total polysaccharides;
Dry extract yielding rate
- From:
China Pharmacist
2014;(5):773-775
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To optimize the ethanol precipitation technique for Fufang Shenqi soft capsules. Methods: An orthogonal design was used to optimize the technique with the relative density of the concentrated solution, ethanol concentration, standing time, temperature of ethanol precipitation as the influencing factors and the yield of dry extract and the content of total polysaccharides as the indices. Results:The best ethanol precipitation technique was as follows:the relative density of the concentrated solution was 1. 10, 95% ethanol was used to obtain 60% ethanol concentration, and the standing time was 48 h under the temperature of 10-30℃. Con-clusion:The optimized ethanol precipitation technique for Fufang Shenqi soft capsules is simple and practicable, and suitable for prac-tical production.
