Determination Optimization of Total Amino Acids in Runing Pills by Orthogonal Design
- VernacularTitle:正交设计优选乳宁丸中总氨基酸的测定工艺
- Author:
Yi WU
;
Yan XU
;
Yingying ZHENG
;
Xin XIONG
;
Dong WANG
- Publication Type:Journal Article
- Keywords:
Orthogonal design;
Runing pills;
Total amino acids;
Determination
- From:
China Pharmacist
2014;(5):775-778
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To optimize the determination technology for the total amino acids in Runing pills. Methods:The process was optimized by L9 (34 ) orthogonal design using the hydrolysis temperature, hydrolysis time and hydrochloric acid concentration as the evaluation factors,and the content and yield of total amino acids as the evaluation indices. Results: The optimal determination condi-tions were as follows:the hydrolysis temperature was 110℃, the hydrolysis time was 22 h and the hydrochloric acid concentration was 6 mol·L-1 . Conclusion:The optimal determination technology can be applied in the total amino acids from Runing pills,which pro-vides the basis for the further research of Runing pills.
