Curative Effect Observation of Ulinastatin Combined with Somatostatin in the Treatment of Acute Severe Pancreatitis
- VernacularTitle:乌司他丁联合生长抑素治疗急性重症胰腺炎疗效观察
- Author:
Fengping WANG
;
Yonglong ZHANG
- Publication Type:Journal Article
- Keywords:
Ulinastatin;
Somatostatin;
Acute severe pancreatitis;
Curative effect
- From:
China Pharmacist
2014;(5):812-814
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To observe the clinical effect of ulinastatin combined with somatostatin in the treatment of acute severe pan-creatitis. Methods:Totally 130 cases of severe acute pancreatitis patients were randomly divided into two groups with 65 cases in each. The control group was given the routine treatment and 3mg somatostatin in 250ml sodium chloride injections, ivd, bid, and the treatment group was given 10ku ulinastatin in 250ml sodium chloride injections additionally, ivd, bid. After the 10-day treatment, the clinical symptom disappearance time, the recovery time of respiratory and heart rate, length of stay, blood and urine amylase, and clin-ical total effective rate were compared between the two groups. Results:The symptom disappearance time, recovery time of respiratory and heart rate and length of stay in the treatment group were all shorter than those in the control group (P<0. 05). The recovery time of serum and urine amylase in the two groups was without significant difference (P>0. 05). The total effective rate of the treatment group was 95. 38%, while that of the control group was 73. 84% with significant difference (P<0. 05). Conclusion:The application of ulinastatin in the treatment of severe acute pancreatitis shows obviously curative effect, which can effectively improve the clinical symptoms and shorten the course of disease, and is valuable in clinical use.
