The expression of caveolin-1 and its clinic significance in the sera of esophageal cancer patients
10.3760/cma.j.issn.1008-1372.2014.02.018
- VernacularTitle:小窝蛋白-1在食管癌患者血清中的表达及其临床意义
- Author:
Suzuan CHEN
;
Ruinuan WU
;
Jing YU
;
Zhaohui LIU
;
Guanghua GUO
- Publication Type:Journal Article
- Keywords:
Desmin/blood;
Esophageal neoplasms/blood;
Tumor markers,biological
- From:
Journal of Chinese Physician
2014;(2):207-210
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression of caveolin-1 in the sera of esophageal cancer patients , and the possibility of caveolin-1 to be the tumor marker of an esophageal cancer .Methods ⑴Western blot was used to detect the expression of caveolin-1 in esophageal cancer cell EC 109 and EC9706;⑵The sera were collected from 43 esophageal cancer patients , 30 benign esophageal lesions, and 50 healthy control men.Enzyme linked immunosorbent assay (ELISA) was used to detect caveolin-1 in serum.Results⑴Western blot showed that caveolin-1 was detected in two types of esophageal cancer cell lines .The level of caveolin-1 in the poor dif-ferentiated EC109 cell line was mush higher than in the well differentiated EC 9706 cell line ( t =3.08 , P =0.035 ) .⑵ ELISA re-vealed that the median level of serum caveolin-1 in 43 esophageal cancers (0.104 ng/ml) was significantly higher than 30 benign e-sophageal lesions (0.075 ng/ml) or 50 healthy control men (0.081 ng/ml) (χ2 =23.16, P =0.001).Conclusions Caveolin-1 may be the tumor marker of an esophageal cancer as its level in esophageal patients was higher than in benign esophageal lesions pa -tients or healthy control men .
