Improvement in Life Quality of Postmenopausal Women with Breast Cancer Operation by Zoledronic Acid and Letrozole
- VernacularTitle:唑来膦酸联合来曲唑治疗对绝经期乳腺癌术后生命质量的改善
- Author:
Shukai DENG
;
Xiaoguang TONG
;
Xiaomin GAN
;
Shufeng MING
- Publication Type:Journal Article
- Keywords:
Zoledronic acid;
Letrozole;
Breast cancer;
Quality of life
- From:
China Pharmacist
2014;(5):801-804
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the treatment effect of zoledronic acid and letrozole on life quality of postmenopausal women with breast cancer operation. Methods:Totally 26 patients were in the control group,and given letrozole,and 23 patients were in the treat-ment group with zoledronic and letrozole. The patients in the two groups were assessed bone mineral density ( BMD) of hip and lumbar vertebrate before the treatment and the 6th and 12th month after the treatment. BALP, CTX, VAS, FACT-B and adverse reactions were also assessed at the 6th and 12th month after the treatment. Results:Improvement of BMD and FACT-B in the treatment group was sig-nificantly better than that in the control group. BALP, CTX and VAS in the treatment group were all decreased more significantly than those in the control group (P<0. 05 or P<0. 01). There was no significant difference in the metastasis between the two groups (P>0. 05). Conclusion:By preventing bone loss and increasing BMD, the combination of zoledronic acid and letrozole can effectively im-prove the life quality of postmenopausal women with breast cancer operation.
