Study on Relationship between Antimicrobial Consumption and Resistance of Escherichia Coli in Our Hos-pital
- VernacularTitle:我院大肠埃希菌耐药率与抗菌药使用量的相关性研究
- Author:
Hualing WEI
;
Shengzhou NONG
- Publication Type:Journal Article
- Keywords:
Escherichia coli;
Antimicrobial;
Resistance;
Relationship
- From:
China Pharmacist
2014;(5):822-824
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the relationship between antimicrobial consumption and resistance of Escherichia coli. Meth-ods:The total antibiotics use density( AUD) and the synchronous resistance rate of Escherichia coli were studied and the correlation between them was analyzed retrospectively using multiple linear regression analysis in our hospital from 2010 to 2012. Results:The re-sistance rate of Escherichia coil to ceftazidime,cefotaxime and aztreonam were negatively correlated with the consumption of piperacillin/tazobactam (r= -0. 700,-0. 717, -0. 647,P<0. 05). A significant positive correlation was found between the resistance rate to ceftazidime and cefotaxime and the consumption of ceftazidime(r=0. 662,0. 601,P<0. 05). The resistance rate to imipenem had a significant positive correlation with the consumption of imipenem(r=0. 685,P<0. 05) as well. Conclusion:A relationship exists be-tween antimicrobial consumption and resistance rate of Escherichia coil. It is necessary to strengthen the management of microbacterial rational use to control and reduce the increase of bacterial resistance.
