Effects of lentinan on bleomycin A5’s inhibition effects in hemangioma- derivedendothelial cell
- VernacularTitle:香菇多糖对平阳霉素抑制血管内皮瘤细胞的增殖的影响
- Author:
Guili FU
;
Yuanquan ZHENG
;
Jingjing LU
;
Meilian HUANG
;
Yan LI
- Publication Type:Journal Article
- Keywords:
hemangioma;
bleomycin A5;
lentinan;
cell proliferation;
apoptosis
- From:
Chinese Journal of Biochemical Pharmaceutics
2014;(2):20-21
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effects of Lentinan on bleomycin A5’s inhibition effects in hemangioma-derived endothelial cell. Methods Hemangioma-derived endothelial cell line EOMA were divided into LTN group (only lentinan treatment), BLE group (only bleomycin A 5 treatment), L+B group (Lentinan and bleomycin A5 treatment) and CON group (no lentinan and bleomycin A5 treatment). Cell proliferation, cell cycle, PI and apoptosis were detected and compared among four groups. Results The differences of absorbance in LBE group was significantly higher than that in L+B group after treatment for d 1-d 7 (P<0.05), but both of them were significantly lower than in CON group and LTN group (P<0.05). The G 0/G 1 stage and apoptosis rate in L+B group was significantly higher than in BLE group(P<0.05), while it was significantly lower in S stage, G 2/M stage and PI(P<0.05). Conclusion Lentinan could significantly promote bleomycin A5’s inhibition effects on hemangioma-derived endothelial cell.
