The vasodilating effects induced by etomidate in aortas of insulin resistant rats
- VernacularTitle:依托咪酯对胰岛素抵抗大鼠胸主动脉的舒血管作用研究
- Author:
Wenxin XUE
;
Jing LI
- Publication Type:Journal Article
- Keywords:
Insulin resistance;
Etomidate;
Aorta;
Endothelial function;
K+channel
- From:
Chinese Journal of Biochemical Pharmaceutics
2014;(2):51-54
- CountryChina
- Language:Chinese
-
Abstract:
Objection To investigate the effects of etomidate on aorta isolated from IR rats, and explore its underlying endothelium-related mechanism(s). Methods The IR animal model was made by feeding rats with high fructose diet for 8 weeks. Aortic rings were isolated and suspended in a tissue bath, and tensions were recorded isometrically. The effects of etomidate on provoked contractions of the rings were assessed in absence or presence of potassium channel blockers or NO-synthase inhibitors. Results Etomidate-induced relaxation in IR rings was greater than NC rings. NG-nitro-L-arginine methyl ester (L-NAME) or glibenclamide (Gli) inhibit significantly etomidate-induced relaxation in IR rings, and the inhibition of Gli was disappeared in endothelial-denuded aortic rings. Conclusion Etomidate cause vasodilation in IR rat aortas by an endothelial-dependent and independent manner. Impaired NO- and KATP channel-mediated relaxation and etomidate-induced increased availability of may involve in endothelial-dependent relaxation of etomidate in IR rat aortas.
