Effect of allicin on abnormal crypt focus production in carcinogenesis Wister rat model
- VernacularTitle:大蒜素对诱癌Wister鼠模型腺窝异常病灶产生的影响分析
- Author:
Jian HUANG
;
Zhu ZHU
;
Wenliang LI
;
Ruize ZHOU
;
Junyu REN
;
Jian DONG
- Publication Type:Journal Article
- Keywords:
Wister rat model;
abnormal crypt focus;
colorectal cancer
- From:
Chinese Journal of Biochemical Pharmaceutics
2014;(2):65-67
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the inlfuence of the allicin on abnormal crypt focus(ACF). in Wister rat model. Methods 60 Wister rats were subcutaneous injected by dimethylhydrazine (DMH), according to 20 mg/kg weight, once a week, feeding 18 weeks continuously. All of the rats were randomly divided into allicin group and non-allicin group, each group was divided into three groups evenly, and put to death at 8, 16 and 24 weeks after medication separately. Large intestines were observed after dyeing. Results Large intestines were divided into ten equally, and all pieces were observed. ACF were almostly distributed in the middle and distal of the large intestines, about in 50%-80%.The basic situation of non-allicin group was as follows:ACF at 8 weeks was 63.97±1.22 on average per each, 16 weeks was 83.97±1.13, 24 weeks was 69.33±2.01. The basic situation of allicin group:ACF at 8 weeks was 9.4±1.12 on average per each , 16 weeks was 7.17±1.33, 24 weeks was 4.97±1.23.The occurrence of ACF in non-allicin group was higher than allicin group, the differences of incidence rate and number of ACF between two groups was significant (χ2=15.88,P<0.01).Conclusion Allicin can significantly reduce the number of ACF in Wister rats, lower the incidence of colorectal cancer, has prevention effect.
