Clinical Effects of Trimetazidine Combined with Salvia Ligustrazine Injections in the Treatment of Unstable Angina in Coronary Heart Disease with Type 2 Diabetes
- VernacularTitle:曲美他嗪联合丹参川芎嗪注射液治疗2型糖尿病并冠心病不稳定心绞痛
- Author:
Xueling HU
;
Guoli JIA
- Publication Type:Journal Article
- Keywords:
Trimetazidine;
Salvia ligustrazine injections;
Unstable angina pectoris;
Diabetes
- From:
China Pharmacist
2014;(4):641-643
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the clinical efficacy of trimetazidine combined with salvia ligustrazine injections in the treat-ment of unstable angina in coronary heart disease with type 2 diabetes. Methods:Totally 76 patients of unstable angina with type 2 di-abetes were randomly divided into the control group and the observation group with 38 cases in each. The control group received trime-tazidine on the basis of the conventional treatment, 20mg,po,tid, while the patients in the observation group received salvia ligustrazine injections additionally, 10ml, ivd,qd. The treatment course was 2 weeks, and the clinical efficacy, blood fat, blood rheology and the other indices were observed after the treatment. Results:After the treatment, the effective rate of the control group and the observation group was 65. 79% and 86. 84%,respectively with statistically significant difference(P<0. 05), the improvement of blood fat and blood rheology in the observation group was better than that in the control group (P<0. 05), the angina frequency and duration, and nitroglycerin consumption in the observation group was significantly lower than those in the control group(P<0. 05). Conclusion:The combination application containing trimetazidine and salvia ligustrazine shows exact clinical efficacy with promising safety and compli-ance, which is valuable in the clinical application.
