Rational Treatment Course of Omeprazole for Critical Patients
- VernacularTitle:危重患者使用奥美拉唑的合理疗程研究
- Author:
Buwu LI
;
Hong ZHU
;
Wenzhao LUO
;
Guoxin HE
;
Zhan ZHAO
- Publication Type:Journal Article
- Keywords:
ICU;
Critical patients;
Omeprazole;
Treatment course;
Stress ulcer;
Gastrointestinal hemorrhage;
Ventilator-associ-ated pneumonia
- From:
China Pharmacist
2014;(4):623-624
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To study the rational treatment course of proton pump inhibitor omeprazole for critical patients in order to improve the prognosis and reduce the hospital stay and treatment expense. Methods:Totally 180 critical patients with APACHEⅡ>10 and mechanical ventilation >48 hours in ICU were selected and randomly divided into 3 groups treated by omeprazole for 1 day, 3 days and 5 days , respectively. The incidence rate of stress ulcer, gastrointestinal hemorrhage and ventilator-associated pneumonia ( VAP) in the three groups was studied, and the ICU stay and expense were also investigated. Results:The incidence rate of stress ul-cer and gastrointestinal hemorrhage in the group with treatment course of 3 days and 5 days were significantly lower than those in the group with 1 day treatment(P<0. 05). The incidence rate of VAP with 3-days treatment was the lowest, compared with 1 day and 5 days treatment, the different was satatistically significant(P<0. 05). The ICU hospitalization time and treatment expense were also significantly different among the three groups, and that in 3-days, group was the lowest(P<0. 05). Conclusion:The 3-day treatment is the most reasonable, which can not only prevent stress ulcer and gastrointestinal bleeding in critical patients, but also reduce the in-cidence of VAP with lowered hospital stay and expense.
