Efficacy and Safety of Intravenous Thrombolytic Therapy with Alteplase in Aged Patients with Cerebral Stroke
- VernacularTitle:高龄脑梗死患者阿替普酶静脉溶栓治疗的安全性与疗效观察
- Author:
Liangtong HUANG
;
Weiwen QIU
;
Genlong ZHONG
;
Xiao PENG
;
Jie RAO
- Publication Type:Journal Article
- Keywords:
Tissue plasminogen activator;
Acute ischemic stroke;
Elderly
- From:
China Pharmacist
2014;(4):625-627
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To explore the safety and efficacy of intravenous thrombolysis therapy with tissue plasminogen activator ( tPA) in aged acute ischemic stroke patients. Methods:The patients treated with intravenous tPA were analyzed and divided into≥80-year group (n=16) and <80-year group (n=79), and 30 hospitalized patients with the age above 80 years without thrombolytic therapy were selected as the control group. The prognosis of the three groups was compared. Results:①The incidence of ICH in the two thrombolysis therapy groups was 13. 9% and 18. 7% in 24h, and that of SICH was 5. 1% and 6. 3% with no significant difference (P>0. 05). ② No significant difference was found in favorable prognosis between the two therapy groups 90 days after thrombolysis (P=0. 771), while very bad prognosis rate was higher in the≥80-year group than in the <80-year group (P<0. 05). ③The≥80 years group had an increased favorable outcome compared with the control group (P<0. 05), while the very bad prognosis rate in the two groups showed no significant difference (P>0. 05). Conclusion:It is safe and effective for old patients to receive IV-tPA throm-bolysis therapy.
