Recent clinical efifcacy and safety analysis of Tinidazole and metronidazole in treatment of severe oral infection’s
- VernacularTitle:替硝唑和甲硝唑治疗加重型口腔感染的近期临床疗效及安全性分析
- Author:
Xiaoping YUAN
;
Lifeng LI
- Publication Type:Journal Article
- Keywords:
tinidazole;
metronidazole;
oral infections;
safety
- From:
Chinese Journal of Biochemical Pharmaceutics
2014;(2):97-98
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study recent clinical efifcacy and safety analysis of tinidazole and metronidazole in treatment of severe oral infection. Methods, 88 cases with severe oral infection(SOI) collected in the third people's hospital of Wenling from April 2012 to April 2013 were divided into observation group (n=45) and control group (n=43) by random number table. Control group were received metronidazole drug treatment, while observation group were treated with tinidazole medication, The efifcacy, recovery duration and adverse reactions were compared between two groups. Results The efficacy of observation group was significantly better than control group, the difference was statistically significant (P<0.05). The average duration of symptoms and wound healing in observation group were (4.8±0.4)hs and (4.3 ± 0.2)hs, which were signiifcantly less than (5.5 ± 0.2)sh and (5.6 ± 0.1)sh in control group(P<0.05).Adverse reactions in observation group were signiifcantly lower than that in control group (P<0.05). Conclusion Tinidazole has a signiifcant effect and less adverse reactions in treatment of SOI.
