The expression and significance of MMP3 in synovium of knee joint of different stage in osteoarthritis patients
10.3969/j.issn.1006-5725.2014.06.019
- VernacularTitle:骨性关节炎患者不同病变程度滑膜中基质金属蛋白酶-3的表达及意义
- Author:
Hongjun HUO
;
Weishan WANG
;
Jinbo DONG
;
Baochi LI
;
Chenhui SHI
- Publication Type:Journal Article
- Keywords:
Osteoarthritis;
MMP-3;
Immunohistochemical
- From:
The Journal of Practical Medicine
2014;(6):895-897
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression and significance of MMP-3 in knee joint synovium of different stage in osteoarthritis (OA) patients. Methods MMP-3 protein were detected by immunohistochemical method in knee synovial tissues from 90 OA patients (the OA group) and OA group was divided into 3 subgroups according to Kellgren and LawrenceX-ray diagnosing standards: the gradeⅠ(n = 30), gradeⅡ (n = 30) and grade Ⅲ subgroups (n = 30). 30 patients were enrolled as control group. Immunohistochemistry was used to detect the expression of MMP-3 protein in the tissue. Results The expression level of MMP-3 protein in OA group was significantly higher that in the normal synovium (P < 0.05). There existed significant difference in the expression of MMP-3 protein between the grade Ⅲ subgroup and the gradeⅠ, or Ⅱsubgroups (P < 0.05). The expression of MMP-3 protein related positively to the severity of OA (r = 0.912, P < 0.05). Conclusion The expression of MMP-3 protein related closely to the pathogenic mechanism of OA. It may serve as an important indicator of early diagnosis and the activity of OA.
