CT perfusion in assessment of cerebral blood flow in hypodense areas of the brain in patients with severe brain injury
10.3969/j.issn.1006-5725.2014.07.007
- VernacularTitle:CT灌注扫描观察重型脑外伤后低密度区的血流变化
- Author:
Huinong QIAN
;
Jian WANG
;
Yougang WANG
- Publication Type:Journal Article
- Keywords:
Brain injuries;
CT perfusion imaging;
Cerebral blood flow
- From:
The Journal of Practical Medicine
2014;(7):1030-1033
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate regional cerebral blood flow (rCBF) in hypodense areas of the brain after severe traumatic brain injury (sTBI). Methods CT perfusion (CTP) was performed in 42 patients with sTBI during the period of 2011 to 2013. According to the findings of CT scans , hypodense lesions were divided into contusion- or infarction-associated regions. Regional cerebral blood volume (rCBV) of < 15 mL/(100 g·min) was used as the threshold of severe ischemia; rCBF, rCBV, and regional mean transit time (MTT) for the hypodense lesions were analyzed, and the incidence of severe ischemia was compared between the two groups. Results A total of 62 hypodense lesions were identified in the patients. 45 of the 62 hypodense lesions were associated with contusion, and 17 of the lesions were associated with infarction. The mean CT density was significantly lower in the hypodense regions than in the contralateral mirror regions (P<0.05), and there was no significant difference in the mean CT density between the two types of lesions (P > 0.05). Cerebral perfusion was significantly lower in the contusion-associated hypodense regions than in the contralateral mirror regions (P<0.05). In the contrast, cerebral perfusion in the hypodense areas associated with infarction did not significantly differ from that in the contralateral mirror regions (P>0.05). A reduction in rCBF<15 mL/(100 g·min) was found in 25 of the hypodense regions associated with contusion, but only one of those associated with infarction. Conclusions Cerebral perfusion in contusion-associated hypodense areas decreases significantly , but not in infarction-associated hypodense areas. Correct identification of cerebral perfusion in the hypodense areas is helpful for developing therapeutic strategies.
