Research progress in interleukin-22 treatment of malignant tumors
10.3969/j.issn.1000-8179.20132026
- VernacularTitle:白细胞介素22在恶性肿瘤中的研究进展
- Author:
Yongping QU
;
Hongchao YAO
;
Chunyuan ZHAO
;
Xin WANG
- Publication Type:Journal Article
- Keywords:
interleukin-22;
tumor;
cytokine;
treatment
- From:
Chinese Journal of Clinical Oncology
2014;(8):542-544
- CountryChina
- Language:Chinese
-
Abstract:
Interleukin-22 (IL-22) is a member of the IL-10 family, which exhibits a similar structure and immune function with IL-10. IL-22 is mainly secreted by Th22, Th1, and Th17 cells, innate lymphoid cells (ILCs), and γδT and NKT cells. IL-22 is mainly in-volved in autoimmune diseases, malignant tumors, and infective diseases. As such, studies have focused on the function of IL-22 cyto-kine in the pathogenesis of various malignant tumors. Studies revealing the expression and pathogenesis of IL-22 in malignant tumors possibly provide a new method to treat and prevent malignant tumors. In our study, the discovery, structural characteristics, and func-tions of IL-22 in malignant tumors are reviewed.
