Diagnostic value combined detecting cardiac troponin T and serum N terminal pro brain natriuretic ;peptide in children with heart failure
10.3969/j.issn.1008-0074.2014.02.06
- VernacularTitle:肌钙蛋白T联合血清氨基末端脑钠肽诊断儿童心衰的价值
- Author:
Guoqing BI
- Publication Type:Journal Article
- Keywords:
Heart failure;
Child;
Natriuretic peptide,brain;
Troponin T
- From:
Chinese Journal of cardiovascular Rehabilitation Medicine
2014;23(2):134-137
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study clinical diagnostic value combined detecting plasma cardiac troponin T (cTnT)and N terminal pro B type natriuretic peptide (NT-proBNP)in children With heart failure (HF).Methods:A total of 73 child HF patients from our hospital Were enrolled as HF group,and another 75 healthy children from Well child clin-ic Were regarded as healthy control group.Concentrations of cTnT and NT-proBNP,and left ventricular ejection fraction (LVEF)Were measured and compared betWeen tWo groups.Receiver operator characteristic curve (ROC) Was used to analyze diagnostic sensitivity and specificity combined detecting cTnT and NT-proBNP.Results:Com-pared With healthy control group,there Were significant increase in concentrations of NT-proBNP [(2486.7±87.5)pmol/L vs.(3573.8±98.2)pmol/L]and cTnT [(0.03±0.01)ng/ml vs.(0.35±0.09)ng/ml],and significant decrease in LVEF [(70.8±5.2)% vs.(42.6±3.8)%]in HF group,P <0.05 all;multivariate Logistic regression analysis indicated that NT-proBNP Was an independent relative factor for LVEF in HF children (OR=1.006,P = 0.012);When NT-proBNP value Was 3200 pmol/L and cTnT value Was 0.08 ng/ml,their sensitivity and specificity Were 89.5% and 85.7% respectively in combined diagnozing child HF,and the area under ROCWas 0.795.Conclusion: Combined detecting cardiac troponin T and N terminal pro B type natriuretic peptide possesses high clinical diagnostic value in children With heart failure.
