The expression and clinical significance of Livin and Caspase-9 in duodenal adenocarcinoma
- VernacularTitle:Livin、Caspase-9在十二指肠腺癌中的表达及临床意义
- Author:
Wenkai NI
;
Dongfeng YU
;
Yi LIU
- Publication Type:Journal Article
- Keywords:
duodenal adenocarcinoma;
Livin;
Caspase-9;
immunohistochemical
- From:
Acta Universitatis Medicinalis Anhui
2014;(3):410-412
- CountryChina
- Language:Chinese
-
Abstract:
The expressions of Livin and Caspase-9 were detected by immunohistochemical technique in 60 duode-nal adenocarcinoma tissues and 30 adjacent normal tissue. The positive expression rate of Livin in duodenal adeno-carcinoma tissues was significantly higher than that of adjacent normal tissue,and the expression of Caspase-9 was lower than that of adjacent normal tissue ( P<0.01 ) . The expression of Livin was negatively correlated with the ex-pression of Caspase-9 ( P<0.01 ) . The expression of Livin and Caspase-9 was closely correlated with the progress of pathological changes, degree of development,lymph nods metastasis,and clinical stages,but not with sex,age and tumor size ( P>0.05 ) . Livin and Caspase-9 were associated with occurrence and development of duodenal adeno-carcinoma,and the expression of the above two were negatively correlated. Livin and Caspase-9 may be considered as reliable markers for clinical diagnosis,therapy efficacy and the prognosis of duodenal adenocarcinoma.
