A randomized controlled study of the mixed- or single-application of etomidate and propofol during modified electroconvulsive therapy (MECT)
10.3969/j.issn.1006-5725.2014.04.039
- VernacularTitle:依托咪酯、丙泊酚混用和单用在无抽搐电休克中的随机对照研究
- Author:
Hongzu ZHAO
;
Erlong CUI
;
Hongxing ZHANG
- Publication Type:Journal Article
- Keywords:
MECT;
etomidate;
propofol;
schizophrenia;
anesthesia
- From:
The Journal of Practical Medicine
2014;(4):615-617
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the feasibility of the mixed- or single-application of etomidate and propofol during modified electroconvulsive therapy (MECT). Methods Ninety hospitalized schizophrenics undergoing MECT were randomly assigned to 3 groups which were respectively anesthetized with mixed liquor application of etomidate and propofol (group E-P), etomidate (E) or propofol (P). Charge delivered (CD), EEG seizure duration (ESD), postictal suppression index (PSI), seizure energy index (SEI) and seizure generalization index (SGI) were recorded. Mental status and memory levels were assessed with the Positive and Negative Syndrome Scale (PANSS) and Wechsler Memory Scale (WMS) before and after treatment. The adverse reactions were recorded. All data were analyzed with the software SPSS12.0. Results The ESD, PSI, SEI, SGI and WMS scores, and the minus score of PANSS were significantly higher (P < 0.05) and CD was lower (P < 0.05) in group E-P than those in group P. No significant alteration between group E-P and group E (P > 0.05). The adverse reactions such as nausea/vomiting and secretion increase in group E-P were lower than those in group E (P < 0.05). The injection pain of group E-P was lower than that of group P (P<0.05). Conclusion The mixed liquor of etomidate and propofol has an advantage over the single-application of the two drugs during MECT.
