Roles of K-ras gene in non-small cell lung cancer
10.3760/cma.j.issn.1673-422X.2014.04.012
- VernacularTitle:K-ras基因在非小细胞肺癌中的作用
- Author:
Liuchun WANG
;
Kai LI
- Publication Type:Journal Article
- Keywords:
Carcinoma,non-small-cell lung;
Prognosis;
Drug resistance,neoplasm;
K-ras gene
- From:
Journal of International Oncology
2014;41(4):276-279
- CountryChina
- Language:Chinese
-
Abstract:
K-ras gene is one of oncogenes in non-small cell lung cancer,and it can promote tumor cells growth after mutations by several signaling pathways.K-ras mutations frequently occur in lung adenocarcinoma patients with smoking history.In the present study,K-ras mutations are associated with resistence to targated therapy and may be a marker of poor prognosis in patients with non-small cell lung cancer.
