Clinical efficacy of sodium tanshinone IIA sulfonate in treatment of advanced schistosomiasis
- VernacularTitle:丹参酮IIA磺酸钠治疗晚期血吸虫病效果
- Author:
Ailin XUAN
;
Lu YOU
;
Weidong JIANG
- Publication Type:Journal Article
- Keywords:
Sodium tanshinone IIA sulfonate(STS);
Advanced schistosomiasis;
Clinical efficacy
- From:
Chinese Journal of Schistosomiasis Control
2014;(2):224-225
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the clinical efficacy of sodium tanshinone IIA sulfonate(STS)in the treatment of ad-vanced schistosomiasis. Methods Fifty cases with advanced schistosomiasis admitted to the Touzao Township Hospital of Dong-tai City during the period from November 2012 to November 2013 were treated with STS for 10 days,and the internal diameter of the portal vein,levels of ALT,AST,γ-GT,PIIIP,CIV,HA and LN were measured and compared before and after the adminis-tration of STS. Results The mean levels of all serological parameters except HA were within the normal range before STS treat-ment,while the highest positive rate was detected inγ-GT(26.0%)and HA(54.0%). Following the STS treatment,the mean lev-els of all parameters and the positive rates reduced,with the greatest reduction observed inγ-GT(36.7%)and HA(37.8%);how-ever,the mean HA level was still higher than the normal range. The mean internal diameter of the portal vein reduced from(10.5± 1.7)mm before the STS treatment to(9.8±1.3)mm after the STS administration,with a significant diffrtence(P<0.05). Conclu-sion STS appears effective in the treatment of advanced schistosomiasis.
