Pharmacokinetics and tissue distribution of irinotecan hydrochloride nanoparticles.
- Author:
Fuying YANG
;
Wenping ZHANG
;
Heli CHEN
;
Yan FU
;
Xinyu WANG
;
Shijie WEI
;
Xiaoying YANG
;
Yuxin ZHANG
;
Hongwan DANG
- Publication Type:Journal Article
- From:
Acta Pharmaceutica Sinica
2013;48(6):940-5
- CountryChina
- Language:Chinese
-
Abstract:
To investigate the pharmacokinetics of irinotecan hydrochloride (CPT-11) in rats and the tissue distribution of CPT-11 in mice after injection of irinotecan hydrochloride nanoparticles (CPT-11 NPs) via tail veins, separately, a LC-MS/MS method was established to determine the concentration of CPT-11 in whole blood of rats and in different tissues of mice. The pharmacokinetics and tissue distribution of CPT-11 were compared after the intravenous injection of CPT-11 NPs and CPT-11 solution. Compared with CPT-11 solution, the elimination half-life of CPT-11 was prolonged from 2.28 h to 3.95 h after the intravenous injection of CPT-11 NPs, and its AUC was 1.47 times than that of CPT-11 solution. After the injection of CPT-11 NPs in mice, the concentrations of CPT-11 loaded in CPT-11 NPs were significantly higher in the whole blood, colon and lungs than those in CPT-11 solution, but lower in the spleen, liver, kidney and heart, but the least in brain. CPT-11 NPs could improve CPT-11 's AUC, and help CPT-11 to reach long circulation activity.
