Detection of mutations of multi-drug resistance 1 genes associated with chloroquine resistant P.falciparum in Binh Phuoc
- Author:
Nakazawa -- Sukuka
- Publication Type:Journal Article
- Keywords:
multi-drug resistance gen, mutation
- MeSH:
malaria;
malaria, falciparum;
Chloroquine;
diagnosis;
mutation;
genes
- From:Journal of Malaria and parasite diseases Control
2003;0(4):52-58
- CountryViet Nam
- Language:Vietnamese
-
Abstract:
The changes of susceptibility to chloroquine associated with mutations at 76 point of transporter membrane gene (P.fcrt) and at 86 point of multi-drug resistant 1 gene (P.fmdr-1) of P.falciparum were investigated by nested PCR. Analysis of 113 P.falciparum blood samples collected from the malaria patients in the Farm No11 of Phu Rieng Rubber Company in Binh Phuoc province in October 2002. The results showed that: at76 point of P.fcrt gene, 58 samples (51%) were wild type, 24 samples (21%) were mutated type and 31 samples (28%) were mixture of wild and mutated type. At 86 point of P.fmdr-1 gene, 3 samples of mixed wild and mutated type (2.7%), 110 samples of wild type (97.3%) and non of mutated type samples
