Progress in the study of BLyS and APRIL on regulating T cell responses in rheumatoid arthritis.
- Author:
Yan CHANG
;
Wei WEI
- Publication Type:Journal Article
- From:
Acta Pharmaceutica Sinica
2013;48(7):979-85
- CountryChina
- Language:Chinese
-
Abstract:
B lymphocyte stimulator (BLyS), a tumor neurosis factor ligand superfamily, is an important factor of B cell survival and activation. However, BLyS also regulates T cell activation and survival, playing key roles in T cell-mediated autoimmune disorders. In the paper, we introduced the mechanisms of BLyS and a proliferation-inducing ligand (APRIL) regulating T cell responses and their roles in rheumatoid arthritis (RA).
