Mesenchymal stem cells-stents complex in repair of meniscus injury in knee joint
10.3969/j.issn.2095-4344.2014.07.018
- VernacularTitle:间充质干细胞-支架复合体修复膝关节半月板损伤
- Author:
Yijun LIU
;
Qiuxia ZHANG
;
Jing TIAN
- Publication Type:Journal Article
- Keywords:
stem cells;
mesenchymal stem cells;
menisci,tibial;
stents;
tissue engineering
- From:
Chinese Journal of Tissue Engineering Research
2014;(7):1088-1093
- CountryChina
- Language:Chinese
-
Abstract:
BACKGROUND:Meniscus injury is a common disease, whose curative effect is not obvious. The clinical application of tissue engineering technology is gradual y rising, and mesenchymal stem cells-stents complex is expected to be used for the treatment of meniscus injury.
OBJECTIVE:To review the application process of mesenchymal stem cells-stents complex in meniscus injury, in order to provide reference for further study and clinical practice.
METHODS:A computer-based online search of PubMed database, VIP database, Wanfang database and China National Knowledge Infrastructure between 1980 and 2013 was performed to search related articles on mesenchymal stem cells-stents complex in meniscus injury. The key words were“mesenchymal stem cell, meniscus injury, tissue engineering, scaffold, stent”in English and“mesenchymal stem cell, meniscus injury, tissue engineering”in Chinese. For the articles in the same field, we preferred the ones published recently or in authorize journals. Meta-analysis and repetitive studies were excluded. 282 articles were included, and final y 59 articles were included according to inclusion criteria.
RESULTS AND CONCLUSION:Nowadays, numerous experiments showed that mesenchymal stem cells could differentiate into chondrocytes both in vivo or vitro. Mesenchymal stem cells-stents complex could be effective to meniscus injury. Although this technique is stil in exploratory stage, it has promising application prospects in treatment of meniscus injury, because it is characterized by convenience to col ect samples, vitality and no antigenicity.
