Neural stem cell transplantation for central nervous system diseases via the cerebrospinal fluid
10.3969/j.issn.2095-4344.2014.06.025
- VernacularTitle:脑脊液途径移植神经干细胞治疗中枢神经系统疾病的研究现状
- Author:
Baohua ZHANG
;
Fucheng QIU
;
Ci DONG
;
Rui HAN
;
Yongzhi ZHANG
;
Huimiao LIU
;
Bingchuan XIE
;
Lina ZHANG
;
Wenting WANG
;
Yanyong WANG
;
Zhenqing ZHANG
;
Ping GU
;
Baoyong YAN
- Publication Type:Journal Article
- Keywords:
central nervous system diseases;
stem cells;
neural stem cells;
stem celltransplantation;
drug administration routes
- From:
Chinese Journal of Tissue Engineering Research
2014;(6):974-978
- CountryChina
- Language:Chinese
-
Abstract:
BACKGROUND:Currently, neural stem celltransplantation can be performed through three main approaches:local lesions, blood circulation, and cerebrospinal fluid.
OBJECTIVE:To review the transplantation of neural stem cells or neural precursor cells via the cerebrospinal fluid in the treatment of central nervous system diseases.
METHODS:A computer-based search of PubMed and CHKD databases was performed to retrieve articles concerning transplantation of neural stem cells via the cerebrospinal fluid, and its application and therapeutic mechanism in the treatment of central nervous system diseases in both animal experiment and clinic study published from 2000 to 2009.
RESULTS AND CONCLUSION:It is suitable for neural stem cellsurvival, proliferation, and differentiation in the cerebrospinal fluid. Transplantation of neural stem cells via the cerebrospinal fluid is effective and feasible to treat central nervous system diseases. However, some problems have not been solved, such as the source of neural stem cells, the optimal time window and celldose, the safety and the long-term effect. Further studies are needed to pave the way for the intrathecal injection of neural stem cells in the treatment of central nervous system diseases.
