Chemotherapy and comparison of agents for advanced duodenal carcinoma
10.3969/j.issn.1000-8179.20131435
- VernacularTitle:晚期十二指肠癌化疗的方案和疗效比较
- Author:
Junbao LIU
;
Chengxu CUI
;
Jinwan WANG
;
Yurong ZHANG
;
Nan WANG
;
Wei LIU
;
Chunhui GAO
;
Shuping SHI
;
Haijian TANG
;
Zhujun SHAO
;
Tingting YANG
- Publication Type:Journal Article
- Keywords:
primary duodenal carcinoma;
palliative chemotherapy;
oxaliplatin;
fluorourzcil;
survival
- From:
Chinese Journal of Clinical Oncology
2014;(5):319-323
- CountryChina
- Language:Chinese
-
Abstract:
Objective:This study aims to determine the efficacy of chemotherapy and to identify potential chemotherapy agents for advanced primary duodenal carcinoma (PDC). Methods:Fifty-six patients with advanced PDC, who did and did not receive chemo-therapy, were involved in this study. Response rates (RR), disease control rates (DCR), progression-free survival (PFS), and overall sur-vival (OS) were analyzed. Results:The overall RR and DCR of 43 patients were 19.04%and 71.42%, respectively. The patients who re-ceived chemotherapy agents fluorourzcil and oxaliplatin exhibited higher RR compared with patients who received other chemotherapy combinations (35.29%vs. 7.69%, P=0.010 9). Palliative chemotherapy improved the OS of patients with advanced PDC compared with patients who did not receive chemotherapy (13.35 months vs. 5.65 months, HR=0.203, 95%CI:0.083 to 0.497, P=0.000 5). Compared with the use of other chemotherapy regimens, treatment with a fluorourzcil-based chemotherapy agent resulted in a longer PFS (5.08 months vs. 1.08 months, HR=0.004, 95%CI:0.000 to 0.315, P=0.013 2). Multivariate analysis indicated mucinous histology and lymph mode metastasis as factors predictive of poor prognosis in patients with advanced PDC. Conclusion:Palliative chemotherapy may im-prove the OS of patients with advanced PDC.
