Expression of Twist in Middle and Advanced Stages Cervical Cancer and Its Clinical Significance
- VernacularTitle:Twist在中晚期宫颈癌组织中的表达及临床意义研究
- Author:
Jie WEI
;
Qin XU
;
Lihua YANG
- Publication Type:Journal Article
- Keywords:
Twist;
Cervical cancer;
Middle and advanced stages;
Expression;
Clinical significance
- From:
Journal of Kunming Medical University
2014;(1):25-27
- CountryChina
- Language:Chinese
-
Abstract:
Objective The purpose of this study was to research the expression of Twist in cervical cancer tissues and the relationship between its expression and clinicopathologic characteristic, and to investigate the role of twist in cervical cancer invasion, metastasis and progress. Methods Immunohistochemistry was used to detect the expression of the Twist in 78 cases of middle and advanced stages cervical cancer tissue microarray chip. The relationship between its expression and clinicopathological characteristic was analyzed. Results (1) The positive expression of twist in cervical cancer was 56/78 (71.8%);(2) The expression of Twist in cervical cancer was significantly related to tumor histology type, FIGO stage, lymph node metastasis and differentiation degree. With the increase of FIGO stage, the emergence of lymph node metastasis and the decrease of differentiation degree, the expression of Twist increased gradually ( <0.05) . Conclusion The expression of Twist may be closely related to the invasion, metastasis and progress of cervial cancer.
